The Dog Cancer Survival Guide (141 page)

Disease-associated Bias in T Helper Type 1 (Th1)/Th2 CD4+ T Cell Responses Against MAGE-6 in HLA-DRB1*0401+ Patients With Renal Cell Carcinoma or Melanoma, Tatsumi, T et al.
J Exp Med
. 2002 September 2; 196(5): 619–628.

Tumor antigen-specific T helper cells in cancer immunity and immunotherapy. Knutson KL, Disis ML.
Cancer Immunol Immunother
. 2005 Aug;54(8):721-8. Epub 2005 Jan 27. Review.

Vegetables

Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo. Srivastava SK, et al.
Carcinogenesis
. 2003 Oct;24(10):1665- 70.

Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. Talalay P, Fahey JW.
J Nutr
. 2001 Nov;131(11 Suppl):3027S-33S. Review.

Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNAreactive dietary carcinogens. Steinkellner H, et al.
Mutat Res
. 2001 Sep 1;480-481:285-97.

Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables. Shapiro TA, et al.
Cancer Epidemiol Biomarkers Prev.
1998 Dec;7(12):1091-100.

Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. Talalay P and Fahey JW.
J Nutr.
2001 Nov;131(11 Suppl):3027S-33S.

Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. Talalay P and Fahey JW.
J Nutr.
2001 Nov;131(11 Suppl):3027S-33S.

Evaluation of the effect of dietary vegetable consumption on reducing risk of transitional cell carcinoma of the urinary bladder in Scottish Terriers. Raghavan M, et al.
J Am Vet Med Assoc
. 2005 Jul 1;227(1):94-100.

Vitamin D and Sunlight

Ecologic studies of solar UV-B radiation and cancer mortality rates. Grant WB.
Recent Results Cancer Res
. 2003;164:371-7. Review.

Ecological studies of ultraviolet B, vitamin D and cancer since 2000. Grant WB, Mohr SB.
Ann Epidemiol.
2009 Jul;19(7):446- 54. Epub 2009 Mar 9. Review.

Current impediments to acceptance of the ultraviolet-B-vitamin D-cancer hypothesis. Grant WB, Boucher BJ.
Anticancer Res
. 2009 Sep;29(9):3597-604. Review.

How strong is the evidence that solar ultraviolet B and vitamin D reduce the risk of cancer?: An examination using Hill’s criteria for causality. Grant WB.
Dermatoendocrinol
. 2009 Jan;1(1):17-24.

Lower vitamin-D production from solar ultraviolet-B irradiance may explain some differences in cancer survival rates. Grant WB.
J Natl Med Assoc
. 2006 Mar;98(3):357-64.

The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates. Grant WB and Garland CF.
Anticancer Res
. 2006 Jul-Aug;26(4A):2687-99.

Sunlight, vitamin D, and ovarian cancer mortality rates in US women. Lefkowitz ES and Garland CF.
Int J Epidemiol.
1994 Dec;23(6):1133-6.

Sunlight-skin cancer association in the dog: a report of three cases. Madewell BR, Conroy JD, Hodgkins EM.
J Cutan Pathol
. 1981 Dec;8(6):434-43.

Canine conjunctival hemangioma and hemangiosarcoma: a retrospective evaluation of 108 cases (1989-2004). Pirie CG, et al.
Vet Ophthalmol.
2006 Jul-Aug;9(4):215-26.

The role of vitamin D in cancer prevention. Garland CF, et al.
Am J Public Health
. 2006 Feb;96(2):252-61.

Vitamin D and intervention trials in prostate cancer: from theory to therapy. Schwartz GG.
Ann Epidemiol
. 2009 Feb;19(2):96-102. Epub 2008 Jul 10.

Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure is limited. Glerup H, et al.
J Intern Med
. 2000 Feb;247(2):260-8.

Impact of oral vitamin D supplementation on serum 25-hydroxyvitamin D levels in oncology. Vashi, PG, et al.
Nutr J.
2010; 9: 60.

Estimates of beneficial and harmful sun exposure times during the year for major Australian population centres. Samanek AJ, Croager EJ, Gies P, Milne E, Prince R, McMichael AJ, Lucas RM, Slevin T;
Skin Cancer Prevention. Med J
Aust. 2006 Apr 3;184(7):338-41.

UK Food Standards Agency Workshop Report: an investigation of the relative contributions of diet and sunlight to vitamin D status. Ashwell M, Stone EM, Stolte H, Cashman KD, Macdonald H, Lanham-New S, Hiom S, Webb A, Fraser D.
Br J Nutr
. 2010 Aug;104(4):603-11.

Low vitamin D status: definition, prevalence, consequences, and correction. Binkley N, Ramamurthy R, Krueger D.
Endocrinol Metab Clin North Am.
2010 Jun;39(2):287-301

Water

Center for Disease Control Statement on water fluoridation and osteosarcoma:
http://www.cdc.gov/fluoridation/fact_ sheets/osteosarcoma.htm

Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research. Richardson SD, et al.
Mutat Res
. 2007 Nov-Dec;636(1-3):178-242. Epub 2007 Sep 12. Review.

Age-specific fluoride exposure in drinking water and osteosarcoma (United States). Bassin EB, et al.
Cancer Causes Control
. 2006 May;17(4):421-8.

Municipal drinking water nitrate level and cancer risk in older women: the Iowa Women’s Health Study. Weyer PJ, et al.
Epidemiology
. 2001 May;12(3):327-38.

Drinking water and cancer. Cantor KP.
Cancer Causes Control
. 1997 May;8(3):292-308. Review.

Effects and interactions in an environmentally relevant mixture of pharmaceuticals. Pomati F, Orlandi C, Clerici M, Luciani F, Zuccato E.
Toxicol Sci
. 2008 Mar;102(1):129-37. Epub 2007 Nov 28.

Ultra-trace analysis of multiple endocrine-disrupting chemicals in municipal and bleached kraft mill effluents using gas chromatography-high-resolution mass spectrometry. Ikonomou MG, et. al.
Environ Toxicol Chem
. 2008 Feb;27(2):243-51.

The asbestos cancer epidemic. LaDou J.
Environ Health Perspect
. 2004 Mar;112(3):285-90.

Asbestos is still with us: repeat call for a universal ban. Collegium Ramazzini.
Int J Occup Environ Health.
2010 Jul- Sep;16(3):351-5.

Cancer incidence and asbestos in drinking water, Town of Woodstock, New York, 1980-1998. Browne ML, Varadarajulu D, Lewis-Michl EL, Fitzgerald EF.
Environ Res
. 2005 Jun;98(2):224-32.

Cancer incidence in relation to asbestos in drinking water in the Puget Sound region. Polissar L, Severson RK, Boatman ES, Thomas DB.
Am J Epidemiol
. 1982 Aug;116(2):314-28.

2008 Associated Press Investigative Series on Water Quality Professor at Harvard Is Being Investigated; Fluoride-Cancer Link May Have Been Hidden, Eilperin, J.
The Washington Post
. Washington, DC. The Washington Post Company; [updated 13 Jul 2005; cited 2 Jan 2009]

Nitrate in public water supplies and the risk of renal cell carcinoma. Ward MH, Rusiecki JA, Lynch CF, Cantor KP.
Cancer Causes Control
. 2007

Dec;18(10):1141-51. Epub 2007 Aug 24. Drinking water and cancer. Cantor KP
. Cancer Causes Control
. 1997 May;8(3):292- 308.

Removal of pharmaceuticals during drinking water treatment. Ternes TA, et al.
Environ Sci Technol
. 2002 Sep 1;36(17):3855- 63.

Fate and removal of pharmaceuticals and illicit drugs in conventional and membrane bioreactor wastewater treatment plants and by riverbank filtration. Petrovic M, et al.
Philos Transact A Math Phys Eng Sci
. 2009 Oct 13;367(1904):3979-4003.

From municipal sewage to drinking water: fate and removal of pharmaceutical residues in the aquatic environment in urban areas. Heberer T, Reddersen K, Mechlinski A.
Water Sci Technol.
2002;46(3):81-8.

Ozonation and advanced oxidation technologies to remove endocrine disrupting chemicals (EDCs) and pharmaceuticals and personal care products (PPCPs) in water effluents. Esplugas S, et al.
J Hazard Mater
. 2007 Nov 19;149(3):631-42. Epub 2007 Jul 28.

Photo Credit: Michelle Brady

Dr. Demian Dressler is internationally recognized as “the dog cancer vet” because of his innovations in the field of dog cancer management, and the popularity of his blog,
www.DogCancerBlog. com
. The owner of South Shore Veterinary Care, a full-service veterinary hospital in Maui, Hawaii, Dr. Dressler studied Animal Physiology and received a Bachelor of Science degree from the University of California at Davis before earning his Doctorate in Veterinary Medicine from Cornell University. After practicing at Killewald Animal Hospital in Amherst, New York, he returned to his home state, Hawaii, to practice at the East Honolulu Pet Hospital before heading home to Maui to open his own hospital. Dr. Dressler consults both dog lovers and veterinary professionals, and is sought after as a speaker on topics ranging from the links between lifestyle choices and disease, nutrition and cancer, and animal ethics. His television appearances include “Ask the Vet” segments on local news programs. Dr. Dressler is the cofounder of Functional Nutriments, LLC, a nutraceutical company, and is the inventor of Apocaps, the first clinical apoptogen formula. Dr. Dressler is a member of the American Veterinary Medical Association, the Hawaii Veterinary Medical Association, the American Association of Avian Veterinarians, the National Animal Supplement Council and CORE (Comparative Orthopedic Research Evaluation). He is also an advisory board member for Pacific Primate Sanctuary. He and his wife, Allison, live on Maui, Hawaii, with their dog, Bjorn, and their cat, Ginsu.

Photo Credit: Michelle Brady

Dr. Susan Ettinger is a staff medical oncologist at Animal Specialty Center in Yonkers, New York, and board-certified by the American College of Veterinary Internal Medicine (Oncology). After earning a B.S. in biology at Tufts University, she received a Doctorate in Veterinary Medicine from Cornell University. She completed her small animal medicine and surgery internship before joining the Department of Radiation Oncology at Duke University Medical Center in Durham, North Carolina, as a research associate and investigator in a five-year NIH program project grant. Dr. Ettinger was also an instructor in the Department of Molecular Medicine and an oncology associate with the Comparative Cancer Program at Cornell. During her residency in medical oncology at The Animal Medical Center in New York City she conducted research in soft tissue sarcomas in dogs. Dr. Ettinger served as a staff oncologist at South Bay Veterinary Associates in San Jose, California, and affiliated with the Veterinary Tumor Institute, a radiation oncology facility in Santa Cruz. After relocating to New York, she became a staff oncologist at Long Island Veterinary Specialists before rejoining Animal Specialty Center. She is well-known for compassionate, comprehensive cancer management with a focus on quality of life and palliative care. She and her husband, Kerry, who is also a veterinarian, live with their two sons, their dog, Matilda, and two cats, Jeter and Raziel, in New York.