Proof of Heaven (21 page)

1. A primitive brainstem program to ease terminal pain and suffering (“evolutionary argument”—possibly as a remnant of “feigned-death” strategies from lower mammals?). This did not explain the robust, richly interactive nature of the recollections.

2. The distorted recall of memories from deeper parts of the limbic system (for example, the lateral amygdala) that have enough overlying brain to be relatively protected from the meningitic inflammation, which occurs mainly at the brain’s surface. This did not explain the robust, richly interactive nature of the recollections.

3. Endogenous glutamate blockade with excitotoxicity, mimicking the hallucinatory anesthetic, ketamine (occasionally used to explain NDEs in general). I occasionally saw the effects of ketamine used as an anesthetic during the earlier
part of my neurosurgical career at Harvard Medical School. The hallucinatory state it induced was most chaotic and unpleasant, and bore no resemblance whatsoever to my experience in coma.

4. N,N-dimethyltryptamine (DMT) “dump” (from the pineal, or elsewhere in the brain). DMT, a naturally occurring serotonin agonist (specifically at the 5-HT1A, 5-HT2A and 5-HT2C receptors), causes vivid hallucinations and a dreamlike state. I am personally familiar with drug experiences related to serotonin agonist/antagonists (that is, LSD, mescaline) from my teen years in the early 1970s. I have had no personal experience with DMT but have seen patients under its influence. The rich ultra-reality would still require fairly intact auditory and visual neocortex as target regions in which to generate such a rich audiovisual experience as I had in coma. Prolonged coma due to bacterial meningitis had badly damaged my neocortex, which is where all of that serotonin from the raphe nuclei in the brainstem (or DMT, a serotonin agonist) would have had effects on visual/auditory experience. But my cortex was off, and the DMT would have had no place in the brain to act. The DMT hypothesis failed on the basis of the ultra-reality of the audiovisual experience, and lack of cortex on which to act.

5. Isolated preservation of cortical regions might have explained some of my experience, but were most unlikely, given the severity of my meningitis and its refractoriness to therapy for a week: peripheral white blood cell (WBC) count over 27,000 per mm
³
, 31 percent bands with toxic granulations, CSF WBC count over 4,300 per mm
³
, CSF
glucose down to 1.0 mg/dl, CSF protein 1,340 mg/dl, diffuse meningeal involvement with associated brain abnormalities revealed on my enhanced CT scan, and neurological exams showing severe alterations in cortical function and dysfunction of extraocular motility, indicative of brainstem damage.

6. In an effort to explain the “ultra-reality” of the experience, I examined this hypothesis: Was it possible that networks of inhibitory neurons might have been predominantly affected, allowing for unusually high levels of activity among the excitatory neuronal networks to generate the apparent “ultra-reality” of my experience? One would expect meningitis to preferentially disturb the superficial cortex, possibly leaving deeper layers partially functional. The computing unit of the neocortex is the six-layered “functional column,” each with a lateral diameter of 0.2–0.3 mm. There is significant interwiring laterally to immediately adjacent columns in response to modulatory control signals that originate largely from subcortical regions (the thalamus, basal ganglia, and brainstem). Each functional column has a component at the surface (layers 1–3), so that meningitis effectively disrupts the function of each column just by damaging the surface layers of the cortex. The anatomical distribution of inhibitory and excitatory cells, which have a fairly balanced distribution within the six layers, does not support this hypothesis. Diffuse meningitis over the brain’s surface effectively disables the entire neocortex due to this columnar architecture. Full-thickness destruction is unnecessary for total functional disruption. Given the prolonged course of my poor neurological function (seven days) and the severity
of my infection, it is unlikely that even deeper layers of the cortex were still functioning.

7. The thalamus, basal ganglia, and brainstem are deeper brain structures (“subcortical regions”) that some colleagues postulated might have contributed to the processing of such hyperreal experiences. In fact, none of those structures could play any such role without having at least some regions of the neocortex still intact. All agreed in the end that such subcortical structures alone could not have handled the intense neural calculations required for such a richly interactive experiential tapestry.

8. A “reboot phenomenon”—a random dump of bizarre disjointed memories due to old memories in the damaged neocortex, which might occur on restarting the cortex into consciousness after a prolonged system-wide failure, as in my diffuse meningitis. Especially given the intricacies of my elaborate recollections, this seems most unlikely.

9. Unusual memory generation through an archaic visual pathway through the midbrain, prominently used in birds but only rarely identifiable in humans. It can be demonstrated in humans who are cortically blind, due to damaged occipital cortex. It provided no clue as to the ultra-reality I witnessed, and failed to explain the auditory-visual interleaving.

1
Seventy percent is “dark energy,” that most mysterious force discovered by astronomers in the mid-1990s as they found incontrovertible proof based on Type Ia supernovas that for the last five billion years the universe has been falling
up
—that the expansion of all of space is
accelerating
. Another 26 percent is “dark matter,” the anomalous “excess” gravity revealed over the last few decades in the rotation of galaxies and galactic clusters. Explanations will be made, but the mysteries beyond will never end.

Atwater, F. Holmes.
Captain of My Ship, Master of My Soul.
Charlottesville, VA: Hampton Roads, 2001.

Atwater, P. M. H.
Near-Death Experiences: The Rest of the Story.
Charlottesville, VA: Hampton Roads, 2011.

Bache, Christopher.
Dark Night, Early Dawn: Steps to a Deeper Ecology of Mind
. Albany, NY: State University of New York Press, 2000.

Buhlman, William.
The Secret of the Soul: Using Out-of-Body Experiences to Understand Our True Nature.
New York: HarperCollins, 2001.

Callanan, Maggie, and Patricia Kelley.
Final Gifts: Understanding the Special Awareness, Needs, and Communications of the Dying.
New York: Poseidon Press, 1992.

Carhart-Harris, RL,
et alia
, “Neural correlates of the psychedelic state determined by fMRI studies with psilocybin,”
Proc. Nat. Acad. Of Sciences
109, no. 6 (Feb. 2012): 2138–2143.

Carter, Chris.
Science and the Near-Death Experience: How Consciousness Survives Death.
Rochester, VT: Inner Traditions, 2010.

Chalmers, David J.
The Conscious Mind: In Search of a Fundamental Theory.
Oxford: Oxford University Press, 1996.

Churchland, Paul M.
The Engine of Reason, the Seat of the Soul.
Cambridge, MA: MIT Press, 1995.

Collins, Francis S.
The Language of God: A Scientist Presents Evidence for Belief.
New York: Simon & Schuster, 2006.

Conway, John, and Simon Kochen. “The free will theorem.”
Foundations of Physics
(Springer Netherlands) 36, no. 10 (2006): 1441–73.

———. “The strong free will theorem.”
Notices of the AMS
56, no. 2 (2009): 226–32.

Dalai Lama (His Holiness the Dalai Lama).
The Universe in a Single Atom: The Convergence of Science and Spirituality.
New York: Broadway Books, 2005.

Davies, Paul.
The Mind of God: The Scientific Basis for a Rational World.
New York: Simon & Schuster, 1992.

D’Souza, Dinesh.
Life After Death: The Evidence.
Washington, DC: Regnery, Inc., 2009.

Dupré, Louis, and James A. Wiseman.
Light from Light: An Anthology of Christian Mysticism.
Mahwah, NJ: Paulist Press, 2001.

Eadie, Betty J.
Embraced by the Light.
Placerville, CA: Gold Leaf Press, 1992.

Edelman, Gerald M., and Giulio Tononi.
A Universe of Consciousness.
New York: Basic Books, 2000.

Fox, Matthew, and Rupert Sheldrake.
The Physics of Angels: Exploring the Realm Where Science and Spirit Meet.
New York: HarperCollins, 1996.

Fredrickson, Barbara.
Positivity.
New York: Crown, 2009.

Guggenheim, Bill and Judy Guggenheim.
Hello from Heaven!
New York, NY: Bantam Books, 1995.

Hagerty, Barbara Bradley.
Fingerprints of God.
New York: Riverhead Hardcover, 2009.

Haggard, P, and M Eimer. “On the relation between brain potentials and conscious awareness.”
Experimental Brain Research
126 (1999): 128–33.

Hamilton, Allan J.
The Scalpel and the Soul.
New York: Penguin Group, 2008.

Hofstadter, Douglas R.
Gödel, Escher, Bach: An Eternal Golden Braid.
New York: Basic Books, 1979.

Holden, Janice Miner, Bruce Greyson, and Debbie James., eds.
The Handbook of Near-Death Experiences: Thirty Years of Investigation.
Santa Barbara, CA: Praeger, 2009.

Houshmand, Zara, Robert B. Livingston, and B. Alan Wallace., eds.
Consciousness at the Crossroads: Conversations with the Dalai Lama on Brain Science and Buddhism.
Ithaca, NY: Snow Lion, 1999.

Jahn, Robert G., and Brenda J. Dunne.
Margins of Reality: The Role of Consciousness in the Physical World.
New York: Harcourt Brace Jovanovich, 1987.

Jampolsky, Gerald G.
Love Is Letting Go of Fear.
Berkeley, CA: Celestial Arts, 2004.

Jensen, Lone.
Gifts of Grace: A Gathering of Personal Encounters with the Virgin Mary.
New York: HarperCollins, 1995.

Johnson, Timothy.
Finding God in the Questions: A Personal Journey.
Downers Grove, IL: InterVarsity Press, 2004.

Kauffman, Stuart A.
At Home in the Universe: The Search for the Laws of Self-Organization and Complexity.
New York: Oxford University Press, 1995.

Kelly, Edward F., Emily Williams Kelly, Adam Crabtree, Alan Gauld, Michael Grosso, and Bruce Greyson.
Irreducible Mind: Toward a Psychology for the 21st Century.
Lanham, MD: Rowman & Littlefield, 2007.

Koch, C., and K. Hepp. “Quantum mechanics and higher brain functions: Lessons from quantum computation and neurobiology.”
Nature
440 (2006): 611–12.

Kübler-Ross, Elisabeth.
On Life After Death.
Berkeley, CA: Ten Speed Press, 1991.

LaBerge, Stephen, and Howard Rheingold.
Exploring the World of Lucid Dreaming.
New York: Ballantine Books, 1990.

Lau, HC, R. D. Rogers, P. Haggard, and R. E. Passingham. “Attention to intention.”
Science
303 (2004): 1208–10.

Laureys, S. “The neural correlate of (un)awareness: Lessons from the vegetative state.” “Trends in Cognitive Science,” in
Cognitive Science
9 (2005): 556–59.